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Inhee Mook-Jung, PhD
Seoul National University College of Medicine
Areas of Interest:
Alzheimer's disease, microglia, gut-brain axis, brain organoid, blood biomarker, tau, Beta Amyloid
Biography & Research:
Education 1982~1986 B.S., Seoul National University 1991~1995 Ph.D.,University of Arizona, U.S.A. Present titles 2020.01-Present Director, Korea Dementia Research Center 2020.01-Present Director, SNU Dementia Research Center 2015.12-Present Member, Korean Academy Science and Technology 2013.01-Present Board member of Directors, Korean Society for Neurodegenerative Diseases 2014-Present Board member of Directors, Korean Society for Integrated Biological Sciences 2014-Present Vice President (2020), Board member of Directors Women’s Bioscience Forum 2016-Present Organizing Committee Member, ADPD international conference 2011-present Associate editor, Journal of Alzheimer’s disease 2004~Present Professor, Dept. Biochemistry & Biomedical Sciences, Seoul National University College of Medicine 2010-Present Member, Alzheimer’s disease Association 1997-presnet Member, Society for Neuroscience, USA Professional Careers 1987~1991 Researcher, UC Irvine 1995~1996 Post-doc, UC San Diego 1996~2003 Assistant/Associate Professor, Ajou University School of Medicine 2008-2013 Director, World Class University, Seoul National University 2012-2014 Director, Graduate School of Biomedical Sciences, Seoul National University 2014-2015 Delegate of Korea, Session of Alzheimer’s disease, OECD 2014-2015 Acting Director, Korean Society for Biochemistry & Molecular Biology 2015-2020.07 Chairman, Department of Biochemistry & Molecular Biology, Seoul National University College of Medicine Honors and Awards 2011 Macrogen Woman Scientist Award, Society for Biochemisty& Molecular Biology 2011 Award from the minister of Education, Science and Technology 2013 Award from the minister of Health & Welfare Department 2013 Global Creative Researcher Award, Seoul National University 2015 Korea Loreal-UNESCO Woman Scientist Award 2018 Seoul National University Research Award 2019 Society for Biochemistry and Molecular Biology, Dong Hun Award 2019 Seoul National University Hospital, Creative Research Award 2019 Korea Science Reporter Award Research Interests 1. Molecular pathogenesis of Alzheimer’s disease (1) Abeta-tau axis (2) Tau propagation in the brain (3) Brain inflammation including microglial function (4) Gut-brain axis (5) Crosstalk between peripheral and CNS immune system 2. Identification of plasma biomarkers for early diagnosis of dementia 3. Therapeutic approaches for Alzheimer’s disease drug development (1) Patient-derived brain organoids and microglia (2) Platform development of drug screening (3) Development of preclinical animal models Recent Publication (selected) 1. A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer’s disease. Cell Meatablism (2019) 30(3):493-507. 2. Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model. Gut (2020) 69(2):283-294. 3. Plasma tau/amyloid beta1-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimer’s disease. Brain (2019) 142(3):771-786. 4. Prognostic plasma protein panel for Aβ deposition in the brain in Alzheimer's disease. Prog Neurobiol. (2019) 183:101690. 5. Amyloid β-induced elevation of O-GlcNAcylated c-Fos promotes neuronal cell death. Aging Cell (2019)18(1):e12872.