Richard Caselli, MD - Neurologist

JAD profile

Affiliation(s): 

Mayo Clinic Arizona

Areas of Interest: 

preclinical Alzheimer's disease, age-related cognitive decline

Biography & Research: 

My background and experience is Behavioral Neurology and Cognitive Science. In addition to a clinically specialized focus on Alzheimer’s disease and related disorders, I have an active clinical research program with longstanding collaborative relationships with a team of imaging scientists, geneticists, neuropsychologists, and other behavioral neurologists. My research has focused on longitudinal cognitive trajectories that show the timing of test decline in advance of symptomatic memory loss in patients at genetically defined risk for Alzheimer’s disease (e.g., Caselli RJ et al. Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. N Engl J Med. 2009 Jul 16; 361(3):255-63. PMID:19605830. PMCID:2928998), as well as non-genetic factors that further influence these trajectories (e.g., Caselli RJ, et al. Cerebrovascular risk factors and preclinical memory decline in healthy APOE epsilon4 homozygotes. Neurology. 2011 Mar 22; 76(12):1078-84. Epub 2011 Feb 16. PMID:21325652. PMCID:3068011). I have served as Clinical Core Director and Associate Director of the current Arizona Alzheimer’s Disease Research Center and PI of a longitudinal cognitive aging study of APOE e4 carriers and noncarriers that includes plasma and serum banking, brain imaging as well as cognitive testing