Daniel Linseman, BSc (Hons) PhD

JAD profile

Affiliation(s): 

University of Denver

Lab URL: 

https://science.du.edu/about/faculty-directory/daniel-linseman

ORCID URL: 

https://orcid.org/my-orcid?orcid=0000-0001-8774-1976

Areas of Interest: 

amyotrophic lateral sclerosis, Alzheimer’s disease, traumatic brain injury, Signal Transduction Pathways that Regulate Neuronal Survival, Mitochondrial Oxidative Stress, Intrinsic Apoptosis, Bcl-2 Family Proteins, Nutraceutical Antioxidants, glutathione, Rho GTPases, Tyrosine Kinases, Biomarkers of Disease Onset and Progression

Biography & Research: 

Research in the Linseman Lab at DU is focused on elucidating molecular mechanisms of neuronal cell death in degenerative disorders and episodes of neurotrauma, with a particular emphasis on amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease), Alzheimer’s disease (AD), and traumatic brain injury (TBI). I am a Professor in the Department of Biological Sciences and a Senior Research Scientist in the Knoebel Institute for Healthy Aging at the University of Denver. I have previously been funded by the NIH (multiple R01s) and the VA (10 years of Merit Review funding) and have more than 80 published papers. I currently have 6 graduate students and 15 undergraduate students working in my lab. In my laboratory, biochemical, immunofluorescence, and molecular biological techniques are used to examine the roles of mitochondrial oxidative stress, neuroinflammation, and intrinsic apoptosis in neurodegeneration and neurotrauma. We utilize mouse models of neurodegenerative disorders (e.g., the G93A mutant hSOD1 transgenic mouse model of ALS and the 3xTg-AD mutant mouse model of AD) and neurotrauma (e.g., a controlled cortical impact mouse model of TBI) to study disease processes in vivo.