Mohamed Hosney,

JAD profile

Associate Editor

Term Expiration: 

12/31/2024

Affiliation(s): 

Cairo University

Areas of Interest: 

molecular biology, ONCOLOGY, Stem Cell Biology, Neurophysiology and its neurodegenerative diseases, Biotechnology, cytogenetics, cell biology, histology, Histochemistry, toxicology, and Cell Culture.

Biography & Research: 

• I am reviewer in several journals (Surgical Oncology, Frontiers in Oncology, Journal of Aging, Journal of Biology and Medicine, Journal of Cancer Research and Therapeutics, Journal of Basic and Applied Zoology, and Instant Journal of Forensic of Science). • I am supervisor of several theses: 1. Effects of cyclamate and saccharine mixture on the secretion of Interleukin-10 and the expression of its receptor in albino mice. 2. Role of Adipose-Derived Mesenchymal Stem Cells (ADMSCs) and Acitretin in regulating α-Secretase ADAM10 Gene in Alzheimer's disease Rat Model. A Therapeutic Approach. 3. Evaluation of miRNAs 155 and 146a affecting NF-KB signaling pathway in Alzheimer’s disease rat model and the role of mesenchymal stem cells. 4. Protective effect of Moringa oleifera leaves extract against cyclophosphamide-induced ovarian dysfunction in rats. 5. Therapeutic and Protective Effect of Withania Somnifera (Ashwagandha) on Induced-Cyclophosphamide Ovarian Dysfunction in Rat Model. 6. Evaluation of miR146a expression in cyclophosphamide induced ovarian dysfunction rat model and the therapeutic potential of Moringa Oleifera. 7. Therapeutic potential of mesenchymal stem cells in cardiomyopathy experimental model in Wistar rats. 8. Protective and Therapeutic effect of Melatonin and/or adipose mesenchymal stem cells against Doxorubicin _induced hepato-renal toxicity in wistar rats. 9. Prevalence Of Interferon Gamma Genetic Polymorphism Among Egyptian Breast Cancer Patients. 10. Evaluation of miRNA 146a affecting NF-Kβ signaling pathway in Cardiomyopathy Wistar rat model and the role of mesenchymal stem cells. 11. Therapeutic potential of mesenchymal stem cells and losartan in doxorubicin – induced cardiomyopathy by monitoring of miR320-a concerning VEGF pathway in rat model. 12. Therapeutic potential of Moringa oleifera leaves extract and/or Mesenchymal stem cells on Ehrlich Ascites Carcinoma in female albino mice. 13. Assessment of the Capability of Mesenchymal Stem Cells and/or Pyrroloquinoline quinone in Compensating the Age-Related Dysfunctions of AMPK Pathway in Wistar Rats. 14. Molecular study on the role of mesenchymal stem cells and/ or Moringa olifeira leaves extract in regulating the aged-related dysfunctions of SIRTUIN pathway in rats. 15. Assessment and optimization of forensic DNA extraction from human skeletal remains for obtaining the most reportable short tandem repeats profiles. 16. Evaluation of the chemical profiling and anticancer activity of Alnus rugosa and Yucca elephantipes leaves’ extracts. 17. New therapeutic approach for Parkinson’s disease in rat model using combined treatment of MSCs And Ashwagandha crude extract Loaded on ZnO Nanoflower. 18. Antitumor activity of selenium nanoparticles decorated with the Citrus limon polysaccharide against breast cancer cell lines. 19. Antitumor activity of selenium nanoparticles decorated with the Citrus limon polysaccharide against colon cancer cell lines. 20. Studying The Action Mechanism of Genes Correlated with Autophagy and Hypoxia in Induced- Parkinson’s Disease Rat Model Treated by Mesenchymal Stem Cells and 'Ashwagandha' Plant Extract. 21. Functional enrichment analysis to investigate the role of Mesenchymal Stem Cells with metformin in Bleomycin-Induced pulmonary fibrosis in rat model. • I supervised Biotechnology graduation project entitled: Combinational therapy of Mesenchymal stem cells and Metformin in bleomycin-induced idiopathic pulmonary fibrosis in rat model. • I supervised Biotechnology graduation project entitled: Therapeutic potential of adipose derived mesenchymal stem cells in Cardiomyopathy experimental model in wistar rats. • I supervised Biotechnology graduation project entitled: Therapeutic potential and anti-apoptotic activity of adipose derived mesenchymal stem cells in Alzheimer’s disease rat models • I am member in Veterinary and Agriculture of IACUC committee from October 2019- till now in Zoology Department- Faculty of Science- Cairo University. • I am member in Basic Science of IACUC committee from January 2018 - October 2019 Zoology Department- Faculty of Science- Cairo University. • I work in Cancer Biology Research Lab (CBRL) from 2008 – till now in Zoology Department- Faculty of Science. • Teaching of Academic Education Undergraduates Theoretical Courses include: 1. 4th year Molecular Biology. 2. Computers and Artificial Intelligence faculty Bio 353 course (Population Genetics). 3. 1st year general Zoology (Cell Biology). 4. 1st year general Zoology (Histology). 5. 3rd year Biotechnology Bt Bio 311 (Proteomics). 6. 3rd year Biotechnology Bt Bio 322 (Advanced Molecular Biology). 7. 2nd year Biotechnology Bt Bio 211 (Genetics). 8. 2nd year Cell biology Z 211. 9. 2nd year for Faculty of Physical therapy (Cell Biology, Molecular Biology, Cancer Biology, and Physiology). • Teaching in college of Oral Medicine and Dentistry- Misr University of Science and Technology (MUST) University for Academic Education Undergraduates Courses 4 years include: 1. First year (Cell and Molecular Biology) 2. First year (Physiology) • Teaching of Academic Education Postgraduates Theoretical Courses include: 1. Premaster for Biotechnology Zc 601 (Molecular Biology). 2. Pre-PhD Zc 765 (Cancer Biology) • Teaching of Academic Education Undergraduates and Postgraduates practical Courses include: 1. 1st year general Zoology practical courses (Histology, Anatomy, Systematic Zoology, Cytology and Embryology). 2. Pre-dental Zoology practical courses (Histology, Anatomy and Systematic Zoology). 3. Pre-vet. Zoology practical course (Systematic Zoology). 4. 2nd Zoology practical courses (Cell Biology and Genetics). 5. 3rd Zoology practical courses (Immunology). 6. 4th Zoology practical courses (Histochemistry and Molecular Biology). 7. 2nd Biotechnology practical course (DNA Technology, Cytogenetics and Cell Biology). 8. 3rd Biotechnology practical course (Proteomics and Genomics). 9. Computers and Artificial Intelligence faculty Bio 251 practical course (Genetics and Cell Biology). 10. Computers and Artificial Intelligence faculty Bio 353 practical course (Population Genetics). 11. Computers and Artificial Intelligence faculty Bio 252 practical course (Molecular Biology). 12. Pre-medical engineering Zoology practical courses (Histology and Anatomy). 13. Diplome practical course (Cytogenetics and Molecular biology) • Teaching of Academic Education Postgraduates Course includes Cytogenetics and Molecular Biology. • I worked in a lot of fields such as: 1. Cytogenetics: I did how to make karyotype, staining of Barr body for identifying the sex of an organism and making of fingerprint for identifying persons. 2. Biotechnology and Molecular biology: I performed the DNA technology techniques and genomics and proteomics such as: (a) DNA extraction from blood of (human, mice and frogs), paraffin tissues of human and soft tissues such as liver, kidney, spleen of (frogs and mice) and breast tissue of human manually and kits. (b) RNA extraction from soft tissues such as breast tissue of human and liver, spleen and kidney of mice manually and kits. (c) Real time PCR since 7 years. (d) Protein extraction from soft tissues such as liver, spleen and kidney of mice. (e) Agarose – gel electrophoresis of extracted DNA and extracted RNA. (f) SDS- Polyacrylamide gel electrophoresis of proteins and small size extracted DNA. (g) Purification of DNA from gel. (h) Performing Polymerization Chain Reaction (PCR) (preparation of PCR reaction) (i) Performing of Western Blotting of Proteins. (j) Using restriction enzymes for cutting in specific sites. (k) Performing DNA methylation of soft tissue such as breast tissue of human. (l) cDNA synthesis. 3. Cell Biology: I performed staining of paraffin section, subcellular fractionation, freeze fraction techniques, immunoflourescence techniques and autoradiography. 4. Histology: Adjusting different tissues by light microscope. 5. Histochemistry: I performed immuno-histochemical techniques for human paraffin breast tissue, staining of wet whole amount, preparation of blood smear and staining of different blood cells and fixation by perfusion and staining of carbohydrates by using different dyes. 6. Tissue culture: I performed different tissue cultural techniques such as (a) Isolation of lymphocytes from human blood. (b) Feeding of tumor cells. (c) Splitting of tumor cells. (d) Freezing of tumor cells. (e) Maintain of condition lymphocytes. (f) Preparation and collection of leukocyte condition media. (g) Collection overnight media free serum. (h) Collection of leukocytes stimulated cell line 7. Immunology: ELISA technique. 6- PUBLICATIONS AND PATENTS: 1. Mohamed Hosney; Radwa Reda Sallam; Mariam Saber Sayed. "Human Genetic as Risk Factors for COVID-19 Progression". Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 15, 2, 2023, 529-561. doi: 10.21608/eajbsc.2023.322926. 2. Mohamed Hosney. "Caveolin-1 As A Novel Therapeutic Target For Breast Cancer: A Review Article". Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 15, 2, 2023, 691-712. doi: 10.21608/eajbsc.2023.327048 3. Elzayat, E.M., Shahien, S.A., El-Sherif, A.A, Mohamed Hosney. Therapeutic potential of stem cells and acitretin on inflammatory signaling pathway-associated genes regulated by miRNAs 146a and 155 in AD-like rats. Sci Rep 13, 9613 (2023). https://doi.org/10.1038/s41598-023-36772-3 4. Elzayat EM, Shahien SA, El-Sherif AA, Mohamed Hosney. miRNAs and Stem Cells as Promising Diagnostic and Therapeutic Targets for Alzheimer's Disease. J Alzheimers Dis. 2023 May 18. doi: 10.3233/JAD-221298. Epub ahead of print. PMID: 37212107. 5. Radwa H. Hamada1, Emad M. Elzayat2, Ahmed A. El-Sherif 3, Mohamed Hosney2*. "Herbal Medicine: Promising Treatment for Chemotherapy-Induced Ovarian Dysfunction." Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology 14, no. 2 (2022): 367-380. 6. Mohamed Hosney1*, Alaa Sakraan1, Asaad.A.M1, El-Deftar M.F2, Emad M. Elzayat1 . Egypt. “Therapeutic potential of adipose-derived mesenchymal stem cells (ADMSCs) with/without taurine in aluminum chloride-induced Alzheimer's disease rat model”. Acad. J. Biolog. Sci. (Zoology) Vol.14 (2) pp211-229(2022). DOI: 10.21608/eajbsz.2022.262121. 7. Noha O. Abu Nasra, Emad M. Elzayat, Kamal M. Dawood, Naglaa M. Hagag, Manal M. Yehya and Mohamed Hosney*, 2022: Regulatory Effect of Adipose-Derived Mesenchymal Stem Cells and/ or Acitretin on Adam10 Gene in Alzheimer's disease Rat Model. Current Stem Cell Research and Therapy; 2022; 17(8). DOI: 10.2174/1574888X17666220302154618. 8. Elzayat Emad M, Asmaa Husein, Yasmine Elbeltagy, Fatma Mohamed, Mohamed Hosney*, 2021: Adipose-Derived Mesenchymal Stem Cells Partially Compensating the Neurodegenerative Signs at The Behavioral, Physiological, and Molecular Levels in AD Rat Model. Egypt. Acad. J. Biolog. Sci. (D-Histology and histochemistry) Vol.13 (2) pp101-118(2021) DOI: 10.21608/EAJBSD.2021.200376. 9. Azza El Amir*, Wajeet Nabil, Marwa M. Eldaly, Mohamed Hosney, 2021: Susceptible Role of Saccharin Mixture in Induction of Inflammation Through Action on Interleukin-10 and its Receptor. Immunobiology 6 (4). 10. Hosney M, Badr AM, Fahmy SR, Afifi A, Baumans V, Gaafar KM. Culture of Care Enhancement in Egypt: The Impact of Laboratory Animal Science Training on Participants’ Attitudes. Alternatives to Laboratory Animals. 2021;49(1-2):49-55. doi:10.1177/02611929211016851 11. Hossam Taha Mohamed, Eslam A. El-Ghonaimy, Mohamed El-Shinawi, Mohamed Hosney, Martin Götte, Wendy A. Woodwarde, Tahani El-Mamlouk, Mona Mostafa Mohamed, 2020: IL-8 and MCP-1/CCL2 regulate proteolytic activity in triple negative inflammatory breast cancer a mechanism that might be modulated by Src and Erk1/2. Toxicology and Applied Pharmacology 401 (2020) 115092. https://doi.org/10.1016/j.taap.2020.115092 12. Ayman S. Mohamed, Mohamed Hosney, Heba Bassiony *, Sarah S. Hassanein, Amel M. Soliman, Sohair R. Fahmy & Khadiga Gaafar, 2020: Sodium pentobarbital dosages for exsanguination affect biochemical, molecular and histological measurements in rats. Sci Rep 10, 378 (2020). https://doi.org/10.1038/s41598-019-57252-7 13. Aya Saber, Mohamed Hosney, Hossam Taha Mohamed, Mohamed Fares, Salwa Sabet, Mohamed El-Shinawi ,and Mona Mostafa Mohamed, 2020: Adipocyte of Obese Breast Cancer Patients Is Characterized by The Overexpression of Caveolin-1 Protein/Mediator the Main Constituent of the Plasma Membrane Vesicles Caveolae That Contain Proteins Contribute to Breast Cancer Progression. Egypt. Acad. J. Biolog. Sci. (D-Histology and histochemistry) Vol.12 (1) pp1-12. 14. Mohamed Fares, Hossam Taha Mohamed, Sherif Abdelaziz Ibrahim, Mohamed Hosney, Mohamed I. Rady, Mohamed El-Shinawi, Mona Mostafa Mohamed, 2019: Incidence of Human Cytomegalovirus in Breast Carcinoma Tissues is Associated with A Higher Expression of Growth Factor Receptor-Bound Protein 2. The Egyptian Journal of Hospital Medicine (April 2019) Vol. 75 (3), Page 2358-2365. 15. Sohair R. Fahmy, Ayman Saber Mohamed, Mohamed Hosney, Hanan Ahmed Issa, Sarah Sayed Hassanein, Amel Mahmoud Soliman, 2019: Hepatotoxicity effect of short-term Bradykinin potentiating factor in cholestatic rats. Toxicology Letters, Doi.org/10.1016/j.toxlet.2019.11.006. 16. Mohamed A. M. Kadry, Hanan R.H. Mohamed, Mohamed Hosney, 2017: Ecological and biological studies on five-lined skink, Trachylepis (= Mabuya) quinquetaeniata inhabiting two different habitats in Egypt. Cellular and Molecular Biology, Doi: 10.14715/cmb/2017.63.11.6. 17. Mohamed Hosney, Salwa Sabet, Mohamed El-Shinawi, Khadiga M. Gaafar and Mona M. Mohamed, 2017: Leptin is overexpressed in the tumor microenvironment of obese patients with estrogen receptor positive breast cancer. Experimental and therapeutic medicine, Doi: 0.3892/etm.2017.4291.