Noa Bregman, MD - Neurologist

JAD profile

Associate Editor

Term Expiration: 

12/31/2025

Affiliation(s): 

Tel Aviv University

Areas of Interest: 

AD: Alzheimer Disease

Biography & Research: 

1. Patterns of cognitive and behavioral changes in Alzheimer's disease: Significant effort is being focused on advancing the early detection of neurodegenerative disease processes, particularly Alzheimer's disease. As part of this effort, recognizing and characterizing subtle cognitive and behavioral changes is crucial. The research I have undertaken in the field has provided valuable insights into specific patterns and their relation to the etiology and prognosis of these diseases. 2. The effect of genetic factors on Dementia with Lewy bodies: Dementia with Lewy bodies is characterized by mixed pathology, including Lewy bodies, neurites, and concomitant Alzheimer's disease pathology. This heterogeneity results in a variable and often non-specific clinical presentation. Mutations in the GBA gene are common among DLB patients worldwide, and their prevalence is particularly high among Ashkenazi Jewish patients, reaching approximately 33%. These GBA mutations significantly impact both clinical presentation and disease pathology, making them a critical focus of research globally. Understanding the influence of common genetic factors on DLB is essential for improving diagnostic accuracy and treatment strategies. Our research has demonstrated that genetic factors significantly affect the presentation and progression of DLB. 3. Preclinical genetic Creutzfeldt-Jakob Disease (CJD): Researching early markers for genetic Creutzfeldt-Jakob Disease (CJD) is crucial for several reasons. Identifying these markers can enable earlier diagnosis, which is essential for patient management and care, as the disease progresses rapidly and is currently untreatable. Early detection also facilitates timely intervention strategies that could potentially slow disease progression, improve quality of life, and extend survival. Furthermore, understanding these markers enhances our knowledge of the disease's underlying mechanisms, contributing to the development of targeted therapies and informing public health strategies to manage and prevent outbreaks.