Sheng-Han Kuo, MD
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JAD profile
Associate Editor
Term Expiration:
12/31/2025
Affiliation(s):
Columbia University
Lab URL:
Areas of Interest:
cerebellum, movement disorders, Ataxia, Tremor
Biography & Research:
Dr. Kuo's lab aims to understand cerebellar circuit dysfunction in disease states and to develop therapeutics for cerebellar disorders. The lab focuses particularly on how cerebellar dysfunction contributes to two highly disabling movement disorder symptoms: ataxia and tremor. Dr. Kuo's team strives to identify common brain circuit alterations underlying ataxia and tremor and to develop targeted therapies to restore normal brain circuit function.
The lab employs multiple approaches, including in vivo recording and optogenetics in mouse models, to study circuit alterations with single-neuron precision. In addition, Dr. Kuo collaborates with individuals affected by ataxia and tremor to perform EEG and fMRI studies. By integrating parallel systems in both humans and mice, the lab facilitates the rapid translation of basic scientific discoveries into clinical applications.
Dr. Kuo's team also conducts high-standard clinical trials to advance therapeutics for ataxia, tremor, and other movement disorders. The ultimate goal is to develop personalized strategies to improve the lives of individuals with neurological disorders.
