Soraya Valles, PhD

JAD profile

Affiliation(s): 

Professor of Physiology; School of Medicine; University of Valencia

Lab URL: 

https://livamar.blogs.uv.es/2022/06/04/laboratory-of-physiology-of-the-nervous-s…

ORCID URL: 

https://orcid.org/0000-0003-4861-4266

Areas of Interest: 

Alzheimer's disease, inflammation, glial cells, oxidative stress, Aging and Cognition; Dementia; Neuropsychology; Neurodegeneration;

Biography & Research: 

In 1996 I obtained my doctoral thesis entitled "Changes in the expression of intermediate filament genes in astroglia during the development of the rat brain: Effect of exposure to ethanol". In it I analysed the events that occur during the early stages of astrogliogenesis during brain development, obtaining an outstanding "Cum Laude" grade. The following year I was awarded the extraordinary doctorate award by the University of Valencia. In 1997, I joined the group of Dr. Eva Qwanstrom and Steve Dower at Hallamshire Hospital (University of Shefffiel, UK), where I stayed for 3 1/2 years identifying a regulatory subunit of the interleukin-1 receptor. There, I was working on immunological processes, cytokines, inflammation, and regulation of the cell matrix. In 2000 I returned to Spain to work on alcohol toxicology (from 2000 to 2004). In that year, I began to work (part-time) in the Department of Physiology, Faculty of Medicine, University of Valencia, where after different positions as a lecturer, I obtained a position of Associate Professor at the University with a laboratory own (Laboratory: Molecular mechanisms of pathology: biochemistry and molecular biology). In March 2021, my government granted me the accreditation of Profesor. In November 2021 I obtained my Profesor position at Department of Physiology in the School of Medicine, University of Valencia. Actually I have a new laboratory with three pre-doctoral students, two lectures, one Associate Profesor, one Profesor and one Merit Profesor. The name of my laboratory is "Physiology of the Nervous System". I have participated in more than 27 research projects and have published more than 50 articles in high-impact journals, in addition to presenting more than 60 communications to international conferences. From 2015: 1.- Aguirre-Rueda D, Guerra-Ojeda S, Aldasoro M, Iradi A, Obrador E, Ortega A, Mauricio MD, Vila JM, Valles SL. Astrocytes Protect Neurons from Aβ1-42 Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1. Int J Med Sci. 2015. Jan 1;12(1):48-56. 2.- Diana Aguirre-Rueda, Sol Guerra-Ojeda, Martin Aldasoro, Antonio Iradi, Elena Obrador, Maria D. Mauricio, Jose Mª Vila, Patricia Marchio and Soraya L. Valles. WIN 55,212-2, agonist of cannabinoid receptors, prevents Amyloid β1-42 effects on astrocytes in primary culture. Plos One. 2015. Abril 13: 10(4). 3.- Benlloch M, Obrador E, Valles S, Rodriguez ML, Sirerol JA, Alcácer J, Pellicer JA, Salvador R, Cerdá C, Saez G, Estrela JM. Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells in Vivo: a Physiological Glucocorticoids- and Nrf2-Dependent Mechanism. Antioxid Redox Signal. 2015 Dec 9. DOI:10.1089/ars.2015.6437. 2015 4.- Aldasoro M, Guerra-Ojeda S, Aguirre-Rueda D, Mauricio MD, Vila JM, Marchio P, Iradi A, Aldasoro C, Jorda A, Obrador E, Valles SL. Effects of Ranolazine on Astrocytes and Neurons in Primary Culture. PLoS One. 2016 Mar 7;11(3):e0150619. doi: 10.1371/journal.pone.0150619. 5.- Aldasoro M, Jorda A, Aldasoro C, Marchio P, Guerra-Ojeda S, Gimeno-Raga M, Mauricio MD, Iradi A, Obrador E, Vila JM, Valles SL. Neuronal Effects of Sugammadex in combination with Rocuronium or Vecuronium. Int J Med Sci. 2017 Feb 23;14(3):224-230. doi: 10.7150/ijms.17545. eCollection 2017. 6.- Mauricio MD, Guerra-Ojeda S, Marchio P, Valles SL, Aldasoro M, Escribano-Lopez I, Herance JR, Rocha M, Vila JM, Victor VM. Nanoparticles in Medicine: A Focus on Vascular Oxidative Stress. Oxid Med Cell Longev. 2018 Sep 26;2018:6231482. doi:10.1155/2018/6231482. 7.- Jorda A, Cauli O, Santonja JM, Aldasoro M, Aldasoro C, Obrador E, Vila JM, Mauricio MD, Iradi A, Guerra-Ojeda S, Marchio P, Valles SL. Changes in Chemokines and Chemokine Receptors Expression in a Mouse Model of Alzheimer's Disease. Int J Biol Sci. 2019 Jan 1;15(2):453-463. doi: 10.7150/ijbs.26703. 8.- Valles SL, Iradi A, Aldasoro M, et al. Function of Glia in Aging and the Brain Diseases. Int J Med Sci. 2019;16(11):1473–1479. Published 2019 Oct 5. doi:10.7150/ijms.37769 9.- de la Torre JC, Olmo AD, Valles S. Can mild cognitive impairment be stabilized by showering brain mitochondria with laser photons? [published online ahead of print, 2019 Nov 5]. Neuropharmacology. 2019;107841. doi:10.1016/j.neuropharm.2019.107841 10.- Estrela JM, Salvador R, Marchio P, et al. Glucocorticoid receptor antagonism overcomes resistance to BRAF inhibition in BRAFV600E-mutated metastatic melanoma. Am J Cancer Res. 2019;9(12):2580–2598. Published 2019 Dec 1. 11.- Pablos A, Ceca D, Jorda A, et al. Protective Effects of Foam Rolling against Inflammation and Notexin Induced Muscle Damage in Rats. Int J Med Sci. 2020;17(1):71–81. Published 2020 Jan 1. doi:10.7150/ijms.37981 12.- Soraya L. Valles, Federico Burguet, Antonio Iradi, Martin Aldasoro, Jose M. Vila, Constanza Aldasoro and Adrián Jordá. Astrocytes and Inflammatory Processes in Alzheimer’s Disease. Book chapter. Astrocytes. IntechOpen. 2020. DOI: 10.5772/intechopen.88746 13.- Jorda A, Campos-Campos J, Iradi A, Aldasoro M, Aldasoro C, Vila JM, Valles SL. The Role of Chemokines in Alzheimer's Disease. Endocrine, Metabolic & Immune Disorders-Drug Targets. January 30, 2020. Doi:10.2174/1871530320666200131110744 14.- Jorda A, Aldasoro M, Aldasoro C, Guerra-Ojeda S, Iradi A, Vila JM, Campos-Campos J, Valles SL. Action of low doses of Aspirin in Inflammation and Oxidative Stress induced by aβ1-42 on Astrocytes in primary culture. International Journal of Medical Sciences. 2020; 17(6): 834-843. doi: 10.7150/ijms.40959. 15.- Jorda A, Aldasoro M, Aldasoro C, Valles SL. Inflammatory Chemokines Expression Variations and Their Receptors in APP/PS1 Mice. J Alzheimers Dis. 2021;83(3):1051-1060. doi: 10.3233/JAD-210489. PMID: 34397415. 16.- Obrador E, Salvador-Palmer R, López-Blanch R, Jihad-Jebbar A, Vallés SL, Estrela JM. The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS. Int J Mol Sci. 2021 Jun 14;22(12):6352. doi: 10.3390/ijms22126352. PMID: 34198557; PMCID: PMC8231819. 17.- Obrador E, Salvador R, Marchio P, López-Blanch R, Jihad-Jebbar A, Rivera P, Vallés SL, Banacloche S, Alcácer J, Colomer N, Coronado JA, Alandes S, Drehmer E, Benlloch M, Estrela JM. Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1G93A Mice. Mol Neurobiol. 2021 Apr;58(4):1345-1371. doi: 10.1007/s12035-020-02188-7. Epub 2020 Nov 10. PMID: 33174130. 18.- Guerra-Ojeda S, Marchio P, Aldasoro M, Valles SL, Genovés P, Mauricio MD, Vila JM. Deleterious effects of levamisole, a cocaine adulterant, in rabbit aorta. Vascul Pharmacol. 2022 Mar 28;144:106992. doi: 10.1016/j.vph.2022.106992. Epub ahead of print. PMID: 35358704.